David Boreanaz ... Angel/Angelus
Charisma Carpenter ... Cordelia Chase (1999-2003)
 Glenn Quinn ... Allen Francis Doyle (1999)
Alexis Denisof ... Wesley Wyndam-Pryce (2000-2004)
J. August Richards ... Charles Gunn (2000-2004)
 Amy Acker ... Winifred 'Fred' Burkle/Illyria (2001-2004)
 Vincent Kartheiser ... Connor (2002-2003)
Andy Hallett ... Lorne (2000-2004)
 James Marsters ... Spike/William the Bloody (2003-2004)